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The drug companies' "bargain prices" seem to fall into three specific categories—high prices, high doses, and purity. They appear to be based on three factors when it comes to clinical and laboratory testing, plus market conditions.
High Prices—Higher Drug Prices
High prices for drugs with relatively low prices could have to do with factors ranging from patent expiration and regulatory costs (which generally increase over time) to differences in their price tags within various countries around the world.
In a study published the medical journal Annals of Internal Medicine in March 2015, researchers looked at the impact of patent expiration. They were able to assess a wide range of drugs, and found that the prices of drugs still had patents in effect a price differential of 3-6 drug use in canada vs us times in the five years after they expired. In comparison, the prices of drugs that were no longer being sold in the U.S. or Europe after being listed on the market were significantly lower than those with patents in place. It was not necessarily true, however, that drugs on their way out of U.S. and European markets would be cheaper, according to the authors.
Pricey Drugs with Higher Doses
The other potential reason could have to do with the drugs and how they were packaged. As the number and amount of doses increased, manufacturers might have added extra costs, according to David Pase, a director of the Center for Study Drug Development at Indiana University (see sidebar). "It probably costs a higher percentage of the initial price to produce one dose of a new drug than it does to produce multiple doses of an older one," he tells The Salt.
It may require more research and development to figure out just how expensive a given combination might be, notes Pase. "That may not make the drug cheaper in short term, but it does make less burdensome to produce the drug," he says. question will be how much money preço mesacol 1200mg companies find it worthwhile to expend on testing a new combination—or the potential benefit from such testing—in the long term. For drugs in the early stages of development, it may very well be the case that a combination of drugs works, or might, as long it costs too much money to test at the current levels, notes Pase.
High Purity
Finally, higher purity could also lead to high profit margins. But is purity really the sole deciding factor on what a patient will pay for drug under its patent term?
Yes, says Christopher Dye, CEO of PharmacyClinic.com and author "The Pharmacists' Price Dictionary," adding, more you know about a drug, especially its chemistry, the more you can understand about its market." In a 2014 review of over 50,000 clinical trial data from Europe alone, Dye and his colleagues found that the most common reason why drugs had relatively high margins was because they used new technologies to deliver their active ingredients and/or a novel combination of different drugs. High-value drugs "used more and different active ingredients to make a high-profit pill than to maximize efficiency of drug development," says Dye.
This is more than just a price-cutting strategy, of course. It may also be because drugs which use multiple to make a single medication, even with the same ingredient, generally cost more per pill for two reasons:
The initial cost of producing one drug may come out of a higher cost for manufacturing, research, and marketing.
Higher ingredient costs translate to in drug formulation, making it less cost-effective to do so create a single dosage for each dose of the various drugs used to make that drug. (See "How Big Is the Profit Margin for Pharmaceuticals?" an overview of drug costs and profits.)
Some companies take advantage of their patents to charge more for drugs that are new, since they cannot be used on existing drugs as part of a combination that was already approved. Some researchers, however, point to "pay-for-delay patenting," according a paper published in the Journal of American Medical Association (Vol. 305, Nos. 1492-1499). "Pay-for-delay is a process involving combination of different patents, where one patent gives certain rights to a company develop certain drug, another patent allows for the drug to be marketed by another company, and the third patent prevents new combination holder from using the drug on existing drugs," wrote the authors, who
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Asacol, which is mesalamine - derivative of 5-aminosalicylic acid. It is prsecribed for treatment and remission maintenance at patients with ulcer colitis (earlier known as nonspecific ulcer colitis) of mild and moderate type.
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